Endocrine Abstracts

Introduction: We study the calcitonin levels measurement in the washout of FNAB needles after sampling each thyroid nodule (FNAB-CT) as an approach to calcitonin normal value in them and distinguish of MTC and to correlate with serum CT (sCT) and cytology FNAB.Material & Methods: 109 consecutive subjects (mean age 53.7±13.4, range 18–85 yr, 79.8% females, 27.5% smokers, 18.3% autoimmune thyroid disease) initially no suspicious for MTC who u...

The high sensitivity C-reactive protein (hs-CRP), mediator of atherosclerotic disease, is known to be a sensitive predictor of coronary heart disease in type 2 diabetes mellitus (T2DM).Aims: To evaluate the relationship of hs-CRP levels to metabolic syndrome (MS) and albuminuria in T2DM.Methods: Four hundred and eighty-eight T2DM subjects were recruited. Patients with hs-CRP ≥10 mg/l, creatinine ≥1.4 mg/dl, chronic infl...

Introduction: Mechanism underlying glucose-mediated development and progression of diabetic complication are incompletely understood. Atrial natriuretic peptide (ANP) is a hormone released by atrial myocytes in response to acute and chronic extracellular volume expansion. Moderate hyperglycaemia (>400 mg/dl) in diabetic rats is associated with an elevation in circulating ANP levels and in GFR (glomerular filtration rate), (1) and play a role in the development of microalbu...

There is a clear relationship between degree of obesity and abdominal obesity with the development of cardiovascular disease.Objective: To assess body mass index (BMI) and waist circumference (WC) as predictors of cardiovascular risk (CVR) in type 2 diabetes mellitus (T2DM) patients.Material and Methods: Cross-sectional study in 452 consecutive out-patients with T2DM who visited our clinic in Madrid, Spain for a routine follow-up. ...

Introduction: Genes involved in common complex disorders such as obesity, type 2 diabetes mellitus (T2DM), dyslipidemia or hypertension are not disease specific, since clinically related disorders also share genetic components. These diseases cluster together in the Metabolic Syndrome, a generalized pathology with increased cardiovascular risk in which insulin resistance is considered a key feature. Cysteine protease Calpain-10 (CAPN10) has been associated with T2DM, polycysti...

Introduction: Resistance to thyroid hormones (RTH) is a genetic disorder caused in 85% of cases by mutations in thyroid hormone receptor beta gene (TRβ). The current information about it in Spanish population is scarce, limited to case reports or short series of patients. Thus, we aimed to describe the clinical, biochemical and genetic features of Mediterranean patients with RTH referred to our institution (one of the referral centres in Spain) for genetic testing during ...